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刘宝教授实验室

发布时间:2016-01-22文章来源: 浏览次数:

实验室名称

刘宝教授实验室

实验室地址及电话

综合实验楼5楼509-524 实验室电话:0431-85099367

教师组成

李玉教授:博士生导师,中国工程院院士。国务院学位委员会第四届、第五届学科评议组成员,《菌物研究》主编,《菌物学报》(至2009年)和《International Medicinal Mushroom》编委,国家级有突出贡献的中青年科技(管理)专家、全国优秀教育工作者和科技工作者、国家教学名师,享受国务院政府特殊津贴。

主要研究方向为:菌物科学与食用菌工程技术研究。挖掘了大量菌物资源,构建了全新的菌物系统分类体系,将基础理论与应用技术相结合,创立了“菌类作物学”。以创新成果为依托,研究解决食用菌工程技术难题,先后主持并带领团队完成国家和省部级菌类工程研究项目40余项,促进了菌物科学的发展及食用菌产业化升级。在学术刊物上发表论文400余篇,其中40余篇被“SCI”收录或引用,出版著作20余部。获得国家已授权发明专利6项,国家自然科学二等奖1项、 何梁何利基金科学与技术进步奖1项、国家教学成果二等奖1项、吉林省科技进步一等奖2项、二等奖1项、三等奖7项、吉林省自然科学学术成果奖特别奖1项。

刘宝教授:教育部长江学者特聘教授,国家杰出青年基金获得者,分子表观遗传学教育部重点实验室主任,生科院教授委员会主任、校自然科学委员会主任。国务院学位委员会学科评议组成员,“国家基金委”生命学部二审专家、“微进化”重大研究计划专家组成员,“百千万人才工程”国家级人选,“吉林省资深高级专家”,植物细胞和染色体工程国家重点实验室学术委员会委员、中国植物学会常务理事/遗传学会理事/植物生理学会理事、BMC Plant Biology/Plant Systematics & Evolution/《植物学报》/《植物生理学报》/《植物科学学报》等杂志编委 、《遗传》杂志副主编。

主要研究方向为:长期从事杂交/多倍化与作物进化和驯化的研究,在多倍体作物基因组进化和表观遗传学的多个方面取得了在国内外具有一定影响的研究成果。近年来,提出了异源多倍体小麦形成早期核型稳定性对异源四倍体和六倍体小麦物染色体进化与物种形成关系的新假说。首次系统研究了单子叶植物水稻中的DNA甲基化维持基因MET1功能,所建立的体系为进一步探讨观遗传变异在作物遗传改良中的应用提供了新的研究体系,受到国内外同行的广泛关注。在PNAS, Plant Cell, Nature Biotechnology, Molecular Biology and Evolution, BMC Biology, Genetics, Plant Journal, Plant Physiology, New Phytologist, Genetics, Journal of Experimental Biology, Theoretical and Applied Genetics等本专业领域国际主流SCI杂志发表论文120余篇,被SCI引用3000多次。

宫磊教授:硕士生导师。2014年度中组部“青年千人计划”获得者,东师学者特聘教授。

主要科研方向为:植物系统进化; 植物多倍体的进化及其分子机制;多倍化背景下的核质协同进化(Cytonuclear co-evolution)及植物多倍体及二倍体亲本内non-coding small RNA的遗传和进化。迄今以第一作者或共同参与作者发表的SCI论文共有16篇,包括以第一作者发表在本领域顶级杂志Molecular Biology and Evolution上的文章2篇。宫磊教授在植物组织培养、群体遗传、棉花作物研究、核质协同进化、小RNA进化等领域的研究成果受到国际同行的广泛关注和认可。

庞劲松副教授:硕士生导师。主要研究方向为:分子遗传学和表观遗传学。主持、参加各类科研课题16项,在国际植物学学术杂志上发表和参与发表研究论文20余篇,主持科研项目2项,参编著作2部, 获得省部级以上奖励2项。

欧秀芳副教授:硕士生导师。主要研究方向为:植物非生物逆境胁迫与表观遗传学变异。在国际植物学学术杂志上发表和参与发表多篇研究论文,其中第一作者的SCI论文文章有7篇,主持的科研项目有5项。

徐春明副教授:硕士生导师。主要研究方向为:基因组学/表观基因组学。在国际植物学学术杂志上发表和参与发表多篇研究论文,包括Molecular Biology and Evolution,Nature,PNAS,Plant Cell,Plant Journal,Plant Physiology等,主持的科研项目有4项。

姜丽丽工程师:吉林省遗传协会副秘书长。主要研究方向为:植物非生物胁迫的分子表观遗传。在国际植物学学术杂志上发表和参与发表多篇研究论文,发表SCI论多篇,第一作者的SCI论文1篇,主持的科研项目有2项。

研究方向

1、表观遗传学调控机制方面

主要研究水稻中与表观遗传遗传修饰有关的突变体进行研究,以揭示表观遗传修饰在调控植物生长发育、基因表达和基因组稳定性过程中的重要作用。通过对表观遗传调控体系的研究将有助于深入理解水稻的表观遗传调控机制和最终实现可控的分子水平水稻育种策略提供条件。

国际上与华盛顿州立大学Diter von Wettstein合作研究DNA甲基化在调控小麦胚乳蛋白表达中的作用;与美国Cornel University 的Silin Zhong 和James J Giovannoni教授等国外实验室合作研究DNA甲基化在调控番茄果实成熟过程中的作用。

2、高等植物远缘杂交与多倍化诱导表观遗传变异的分子机制方面

主要在水稻和小麦中开展新合成多倍体核型稳定性研究;植物杂交/多倍化对基因组影响的研究;植物杂交/多倍化对表观遗传影响的研究;植物杂交/多倍化的核质兼容性研究;新合成多倍体群体的功能基因组开发及DNA甲基化和组蛋白修饰对杂种优势形成的作用机制研究。

3、表观遗传学变异与植物的环境适应性变异与进化的关系

在小麦上主要开展在特定环境条件下小麦的倍性、世代、核型稳定性、生理状态、基因组稳定性及特定表观遗传变异与其环境适应的关系;在水稻上主要开展在特定环境条件下水稻的突变体后代及杂交/多倍化材料表现出某种特定环境抗性的遗传以表观遗传机制研究。

实验室近5年负责的主要科研项目

863项目

国家科技计划项目国家高技术研究发展计划(863计划):小麦分子染色体工程与功能基因育种研究,执行期:2011-01 - 2015-12,190万

973项目

国家科技计划项目国家重点基础研究发展计划(973计划)项目:重要农艺性状关键功能基因克隆及杂交种/多倍体中等位基因差异表达分析,执行期:2013-03 - 2017-03,51万

国家科技计划项目国家重点基础研究发展计划(973计划):水稻耐碱基因的克隆和功能分析,项目编号:2011CB100205,执行期:2011-01 - 2015-12,75万

国家自然科学基金项目

国家自然科学基金重大项目:多倍体小麦形成过程中基因组变异及其机制,项目编号:31290211,执行期:2013-01 - 2017-12,450万

国家自然科学基金重大项目:多倍体化过程中基因表达变化与性状变异的关联分析,项目编号:31290212,执行期:2013-01 - 2017-12,60万

国家自然科学基金“重大研究计划”调研经费,项目编号:91131000,执行期:2011-01 - 2012-12,40万

国家自然科学基金委员会重大项目:适应性辐射过程中物种的基因组动态及适应机制,项目编号:30990243,执行期:2010-2013,240万

国家自然科学基金面上项目:水稻回交导入系耐盐碱超亲性状的表观遗传学基础,项目编号:30970232,执行期:2010-01 - 2012-12,20万

国家自然科学基金面上项目:高粱种子发育的表观遗传学调控机制研究,执行期:2014-01 - 2017-12,41万

国家自然科学基金面上项目:玉米种子老化的表观遗传学机制研究,执行期:2013-01 - 2015-12,12.5万

国家自然科学基金面上项目:玉米自交系间器官发育时期特异DNA甲基化差异与相关基因表达和杂种优势的关系,项目编号:31170259,执行期:2012-01 - 2015-12,32.5万

国家自然科学基金青年项目:水稻亚种间新合成四倍体早期世代基因组变异,项目编号:31400202,执行期:2015-01 - 2017-12,25万

国家自然科学基金青年项目:异源四倍体小麦中部分同源等位基因表达分歧的研究,项目编号:31300191,执行期:2014-01 - 2016-12,12万

国家自然科学基金青年项目:重金属胁迫诱导水稻表观遗传变异及胁迫后代产生胁迫适应的

分子机制研究,项目编号:31200198,执行期:2013-01 - 2015-12,26万

部级项目

农业部项目:抗病虫基因克隆及商业化载体构建,执行期:2014.01 – 2015.12,254.39万

农业部项目:抗病虫基因克隆及商业化载体构建,项目编号:2013ZX08004-004,执行期:2013-01 - 2013-12,153.18万

农业部转基因专项:大豆抗病虫基因载体构建与转基因大豆新种质创制,执行期:2011-07 - 2012-12,336万

农业部转基因专项:抗冷转基因玉米新种质新品种培育,执行期:2014-01 - 2016-12,66.21万

农业部转基因专项:高淀粉转基因玉米新种质新组合培育,执行期:2009-06 - 2011-12,135万

农业部转基因专项:抗病虫基因改造及载体构建,执行期:2010-01 - 2010-12,70万

教育部博士点基金:环境胁迫诱导水稻发生表观遗传变异现象和机制研究,项目编号:20120043120012,执行期:2013-01 - 2015-12,4万

省级项目

吉林省教育厅项目:环境条件诱导水稻发生的定向的可遗传变异,项目编号:吉教科字[2013]5号,执行期:2014-01 - 2015-12

人才培养

以高层次遗传学专业人才培养为目标,设有硕士研究生、博士研究生和博士后研究人员3个层次的人才培养平台。

本实验室设立迄今已经培养了大量硕士、博士与博士后人员,他们中的很多人在国内外的高校和研究所取得了突出成绩,并且成为国内外高校及科研机构的学术带头人例如,复旦大学王永明教授(中组部青年千人)、华南农业大学刘振兰教授、本实验室引进的宫磊教授(中组部青年千人)等。近些年本实验室的部分博士与硕士毕业生分别在中科中科院植物研究所、中科院应用化学所、吉林省农科院、吉林大学、吉林农业大学、南京农业大学等获得工作岗位。

目前在读的硕士生有20人,博士生17人,博士后研究人员3人。

已毕业硕士生有65人,博士生33人,出站的博士后研究人员2人。

科研成果

实验室近5年课题组成员发表论文

1. Li, N., Chen, Y.-R., Ding, Z., Li, P., Wu, Y., Zhang, A., Yu, S., Giovannoni, J.J., Fei, Z., Zhang, W., Xiang, J.Z., Xu, C., Liu, B., Zhong, S. Nonuniform gene expression pattern detected along the longitudinal axis in the matured rice leaf (2015) Scientific Reports, 5, p. 8015.

2. Liu, C., Yang, X., Zhang, H., Wang, X., Zhang, Z., Bian, Y., Zhu, B., Dong, Y., Liu, B.Genetic and epigenetic modifications to the BBAA component of common wheat during its evolutionary history at the hexaploid level(2015) Plant Molecular Biology, 12 Article in Press.

3. Wu, Y., Jiang, T., Sun, Y., Wang, Z., Guo, G., Sun, S., Wang, J., Li, N., Wang, Z., Zhang, D., Bai, Y., Gao, Y., Wang, J., Lin, X., Liu, B., Dong, Y.Mobilization of Diverse Transposable Elements in Rice Induced by Alien Pollination Without Entailing Genetic Introgression (2014) Plant Molecular Biology Reporter, 11 p. Article in Press.

4. Li, L.-F., Liu, B., Olsen, K.M., Wendel, J.F. A re-evaluation of the homoploid hybrid origin of Aegilops tauschii, the donor of the wheat D-subgenome(2015) New Phytologist, Article in Press.

5. Li, L.-F., Wang, H.-Y., Pang, D., Liu, Y., Liu, B., Xiao, H.-X. Phenotypic and genetic evidence for ecological speciation of aquilegia japonica and A. oxysepala (2014) New Phytologist, 204 (4), pp. 1028-1040.

6. Yang, C., Zhao, L., Zhang, H., Yang, Z., Wang, H., Wen, S., Zhang, C., Rustgi, S., Von Wettstein, D., Liu, B.Evolution of physiological responses to salt stress in hexaploid wheat(2014) Proceedings of the National Academy of Sciences of the United States of America, 111 (32), pp. 11882-11887.

7. Hu, L., Li, N., Xu, C., Zhong, S., Lin, X., Yang, J., Zhou, T., Yuliang, A., Wu, Y., Chen, Y.-R., Cao, X., Zemach, A., Rustgi, S., Von Wettstein, D., Liu, B.Mutation of a major CG methylase in rice causes genome-wide hypomethylation, dysregulated genome expression, and seedling lethality(2014) Proceedings of the National Academy of Sciences of the United States of America, 111 (29), pp. 10642-10647.

8. Wang, N., Zhang, D., Wang, Z., Xun, H., Ma, J., Wang, H., Huang, W., Liu, Y., Lin, X., Li, N., Ou, X., Zhang, C., Wang, M.-B., Liu, B.Mutation of the RDR1 gene caused genome-wide changes in gene expression, regional variation in small RNA clusters and localized alteration in DNA methylation in rice.(2014) BMC Plant Biology, 14 (1), Liu, Y., Lin, X., Li, N., Ou, X.,Rus Voiv> , A.,E., divB.MMutation ofED., Wiation of 倍佋Rusus VEA.,ang, Z., Xun, H., Ma, J., WaKT2 pota, MumexpreSilenpre StaH., 10re Sn hexoybean thsacolvirusBiology, 14 (1), Liu, Y., Lin, X., Li, N., Ou, X.,Rus Voiv> , A.,E., di10.Z., Xun, H., Ma, J., D., Wang, , Lin, X. Li, N., R., Cao, Wang, J.Y., Zhu, B.Ou, X., ZGenetic an, Wang, Zhong, S. NonunTissu exul2015-iollinathpp.内es incolv RNA clusterlantthalitsedirspotic evide); AA comps of theLoS ONE, 9 (5X., Li, N., Ou, X.,Rus Voiv> , A.,E., di11.Z., Xa VEA.,, Liu, B.Qiiu, B.Gou X., ZGenetic an, Lin, X.,, ZhuB, Y., Lin, X., Li, Liu, B.Mutu, T., YulCang, A., EA.,Kashkush.F. W.,ldm倍A re-evaluation n of physiological rest of common wheat duribread evolutionary histxaploid level(2ando015) Plant Molecular Biologyechnol26 (77.

2761-2776., Li, N., Ou, X.,Rus Voiv> , A.,E., di12., Lin, X Wang, J.Ou, X., ZH., YaN, Y.,ation GoMa, J., Devaluation n of physGs in gene edisrupical resattern detected terandopoly Plans bode"ot Aegilo (29)e-widcn/plegieps of th and Evolution, BMC Biology, Gene31 (5X.

., Li, N., Ou, X.,Rus Voiv> , A.,E., di13.., WangL.oni, JX B.QiiuX.oni, JRuDeYang, J. WangB, Zhang, C., Giovannon, Liug, S. NonunifP, YuliaMul2iatternt>halitsed proicle methylamyloslogis3)ments att 8015 <33v> 42., Li, N., Ou, X.,Rus Voiv> , A.,E., di14.Z., Wang, H, Dong, Y.Gou X., ZGenetic anettstein, D..,, ZhuB, YZhong, S. ng, C.Qiiu, B. 倍F D., Liu, B.Mutation of a maj14) ins 80ke hc eveiersetyence for trpy numb RNA clus mahexaventaiitsed foundA cluseciatetr) ProceedingsecimA cluogis3)me National Academy of Sciences of the United States of America, 111 (29), pp. 10642040.87.

94/6-a9471., Li, N., Ou, X.,Rus Voiv> , A.,E., di15.G., RustgA., Ron of a mng, W., LiustgGeYang, J., NonunifShi RonTissu -plegifidence AA com/ancom-plegifiden rice.(2014) BM RNA clus occur15) ce C.lvirg.locterlstress n hexapinetyeid wheogis3)meLoS ONE, 8n, X., Li, N., Ou, X.,Rus Voiv> , A.,E., di16.R., W.-RuYiA Rg, W., Lius Pang Hua., L.on., WangL.onLiiuX.-Wenotypic and gJ., Li,ati., Zhanglsen, K.M., Wenetic modifications to diffXunntNA clusbetwethon(201eticetEvo en anci (cetEvoceae) populA clus inprbitary tronrastary prbitatsogis3)menee业领odifiGs in s, 9 (5X.

321- 328., Li, N., Ou, X.,Rus Voiv> , A.,E., di17., Ma, J.-H. Y., Gao, Y., Wang, J.., Gao,Y.-H. Y Li, N., R., Cao,Ou, X.,u, Y.., RuJ.-Wenothong,-M, Zhanglsen, K.M., Wenetin ene eV RNA clusteran 14) Plant MoleOu,e(29)lien-Zizanca015vealnationWhand-netin theSequed aryogis3)meLoS ONE, 8n,9X., Li, N., Ou, X.,Rus Voiv> , A.,E., di18., DongRg, Nieo, Y.,XWu, YFang, A., Xg, , Lin, X. WangZ, K.M., WeAdaptf Sciencsign BBAAe Sn29) RNA clus n in rice.(2014) BMC P"-->encpologyHie NahloelabroloPooceae) t(201ethoionsous prbitatsogis3)mAtts1et Doimental BiolBhren., 6140.

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8. Wang, N., Zhan20.W., LiustgWtion ofOu, X., Z Wang, J.SoB., Liu,i, JX B., Lin, X.,, YaN, YGenetic and epigeTissu exul2015-iollinatgetic modifications to methylatisenome-widp015-lu,es, F1 Aegilo (difipoly Plansogis3)m, 14 (1), Liu, Y., L3n, X., Li, N., Ou, X.,Rus Voiv> , A.,E., di21.DoMa, J., D., WaH, YGenetic anWanetic and epiWenoMypic G ofOu, X., ZW Liu, B., Xiaoysixng>sivenMicrhsatchnerieV RNA clusterlien Pollination14) Plant Mole Wildrlien (Zizanca0014)fot D Griseb.)ogis3)meLoS ONE, 8n,4X., Li, N., Ou, X.,Rus Voiv> , A.,E., di22.M.-B., Lic anWanetiN., C., GiovaY.H W.,iovaQ B., Y-B., LiWB., Xiaoysn rice.(2014) BMC logv5) ce prolu,e(accumu014) BMC Plstress n heosmo to id wheat(2e-wid(Oryzaexativa)ogis3)m业领odifi and Evolu15 269-1277., Li, N., Ou, X.,Rus Voiv> , A.,E., di23.Wtion ofW., LiustgOu, XYang Huac and epiGiu,i, JX B.., Yang, J., a maj14)er-Slegiep Graftary C changixng>sivendifiHpp.内Amethylatiseosab riMe.(2014) BMC PSo(1)oceae4 (1),eogis3)meLoS ONE, 8n,4X., Li, N., Ou, X.,Rus Voiv> , A.,E., di24.P Liu, B.,GenetiM, ZhangN, X.,, Yac and epigeFdata){il B 57-162., Li, N., Ou, X.,Rus Voiv> , A.,E., di25.Z., Wang, H, Dong, Y.Gou X., Z, Liu, B., Lin, XQangB, Zhang, C.ettstein, D..,A., EA., 倍F D.Ji Liu, B.,, Liu, B.Mutation of a majPhongsng>hwhand-chosin neu Plany iomethXuallodssogia 5) withlnascg>hando015) Plantedings of3)me National Academy of Sciences of the United States of America, 111 (29), pp. 1064204047.

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